Invited Review HIGHLIGHTED TOPIC Pulmonary Circulation and Hypoxia Hypoxic pulmonary vasoconstriction: role of ion channels
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چکیده
Mauban, Joseph R. H., Carmelle V. Remillard, and Jason X.-J. Yuan. Hypoxic pulmonary vasoconstriction: role of ion channels. J Appl Physiol 98: 415–420, 2005. doi:10.1152/japplphysiol.00732.2004.—Acute hypoxia induces pulmonary vasoconstriction and chronic hypoxia causes structural changes of the pulmonary vasculature including arterial medial hypertrophy. Electroand pharmacomechanical mechanisms are involved in regulating pulmonary vasomotor tone, whereas intracellular Ca serves as an important signal in regulating contraction and proliferation of pulmonary artery smooth muscle cells. Herein, we provide a basic overview of the cellular mechanisms involved in the development of hypoxic pulmonary vasoconstriction. Our discussion focuses on the roles of ion channels permeable to K and Ca , membrane potential, and cytoplasmic Ca in the development of acute hypoxic pulmonary vasoconstriction and chronic hypoxia-mediated pulmonary vascular remodeling.
منابع مشابه
Sustained Hypoxic Pulmonary Vasoconstriction in the Isolated Perfused Rat Lung: Effect of α1-adrenergic Receptor Agonist
Background: Alveolar hypoxia induces monophasic pulmonary vasoconstriction in vivo, biphasic vasoconstriction in the isolated pulmonary artery, and controversial responses in the isolated perfused lung. Pulmonary vascular responses to sustained alveolar hypoxia have not been addressed in the isolated perfused rat lung. In this study, we investigated the effect of sustained hypoxic ventilation o...
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